ReadyCell Barrier Models: Predicting Human Drug Absorption In Vitro
Understanding and optimizing intestinal absorption is critical for the success of orally administered drugs. Yet, predicting human permeability early in development remains a key ADME challenge. This scientific webinar brings together expert insights on leveraging ReadyCell’s Caco-2 and MDCK cell-based models to accurately simulate human intestinal barriers. Learn how these in vitro platforms enable comprehensive assessment of passive diffusion, active transport, and efflux, guiding compound selection and formulation decisions. Through interpretation of Papp values, efflux ratios, and TEER measurements, participants will gain practical strategies to support BCS classification and de-risk IND-enabling studies. The session will also highlight real-world applications of ReadyCell’s barrier systems in lead optimization and early-stage ADME screening.
Speaker: Dr. Swati Chitrangi, PhD
Dr. Swati Chitrangi is a highly accomplished life sciences leader with over 16 years of experience driving innovation at the intersection of drug discovery, ADME-Tox science, and strategic product management. As Head of Product Management – ADME-Tox at Krishgen Biosystems, she leads the development and global rollout of advanced in vitro technologies, with a core focus on humanized models and regulatory-compliant assay platforms for the pharmaceutical, biotech, and academic sectors
Armed with a PhD in Biological Sciences and executive business training from IIM Lucknow, Dr. Swati blends deep scientific insight with strategic commercial acumen. Her expertise spans 3D cell culture systems, organoids, in vitro toxicology, and translational ADME platforms. She has held leadership and scientific roles at Advancells Group, Yashraj Biotechnology, and IIT Bombay, and conducted internationally recognized research at AIST, Japan.
A sought-after speaker and thought leader, Dr. Swati regularly presents at prominent industry forums including CPHI, IMAPAC, ISSCR, and AIIMS Delhi. She is a passionate advocate for non-animal, human-relevant testing models in line with emerging global regulatory frameworks such as the FDA Modernization Act 2.0. Her scientific work is widely published in peer-reviewed journals such as Stem Cell Research, Journal of Tissue Engineering and Regenerative Medicine, BMC Cancer, and Toxicology in Vitro.
Key Learning Objectives
- Discover ReadyCell’s ready-to-use models: CacoReady, CacoGoblet, PreadyPort & PreadyTake
- Predict drug absorption, efflux & transport mechanisms
- Analyze key data: Papp, TEER & Efflux Ratio
- Align studies with BCS & IND regulatory needs
- Learn from real-world case studies in drug discovery
Ideal for: Researchers | DMPK Scientists | ADME-Tox Teams | Formulation Experts